Lorenzo wins Italian MotoGP Mugello 2012, Stoner off
Starting from his second pole of the year, Dani Pedrosa led the charge into the first turn, but Lorenzo sliced under his fellow Spaniard at the apex and never looked back.
The fight for third kept the fans entertained, while reigning world champion Casey Stoner ran off track and could only manage an eighth place finish.
Fastest in every session bar qualifying, where he had suffered an electronic glitch, Lorenzo's superior pace saw him break the slipstream that normally makes Mugello races so close and - after waving to fans during the final lap - won by 5.223s at the end of the 23 lap distance.
Lorenzo's fifth win from nine races extends his lead to 19 points over Pedrosa, who briefly dropped to third behind Yamaha Tech 3's Andrea Dovizioso, before retaking and then comfortably securing the runner-up spot.
Pedrosa set the fastest race lap, but couldn't match Lorenzo's consistency.
Dovizioso defied his third row start to be in the podium battle from the first turn. Overtaken by charging rookie Stefan Bradl during the middle stages, Dovizioso clung to the Honda LCR rider and retook third at turn one with three laps to go.
The Italian then claimed his fourth podium in five races by holding off Bradl by just 0.046s at the line.
Nicky Hayden was the leading Ducati rider for almost the entire race and slipstreamed into the Dovizioso-Bradl podium fight as the last lap began.
Hayden then pounced quickly to pass Bradl, but was pushed wide when the German retaliated, dropping him behind team-mate Valentino Rossi.
Rossi initially remained where he had qualified, in tenth, but made forward progress from lap 3 onwards - helped by the fastest top speed of the weekend at 346.9km/h.
Dovizioso's team-mate Cal Crutchlow - who had followed Rossi up the order throughout the race - also got by Hayden on the final lap, leaving the American an undeserved seventh.
Stoner crossed the line 30 seconds from Lorenzo in eighth and is now 37 points behind in the championship.
Stoner began the grand prix fifth on the grid, after struggling to find an optimum set-up all weekend and was the only rider to choose the 'special' hard construction rear, offered as an additional harder-spec option as a precaution following the Assen issues.
The Australian moved gradually up the order from eighth on lap one to fifth, in front of Hayden, when he ran through the gravel after missing his braking point into a downhill right-hander just before the halfway stage.
Stoner rejoined in tenth and later passed San Carlo Honda Gresini's Alvaro Bautista (with a little contact) and Pramac Ducati's front row starter Hector Barbera.
Ben Spies suffered another nightmare race, dropping from seventh to eleventh and last of the manufacturer riders.
Leading CRT rider Randy de Puniet (Aspar) finished just two-seconds behind Spies' Factory Yamaha, while Aleix Espargaro (Aspar), James Ellison (PBM) and Mattia Pasini (Speed Master) completed the point scorers.
Ivan Silva (BQR) was the final finisher, one lap down in 16th.
Colin Edwards was among the retirements on what is rumoured to have been his final race on the Suter-BMW - the Forward Racing team being expected to test rival machines on Monday.
Greisni's Michele Pirro was disqualified for taking a short cut back to the pits after problems on the opening lap.
Cardion AB Ducati's Karel Abraham, who suffered left hand injuries sustained in testing at Aragon, missed Mugello and was not replaced.
Mugello was the third event in the space of three weeks. MotoGP teams and riders will return on Monday for a day of testing, then enjoy a weekend off before the US Grand Prix at Laguna Seca.
Honda will provide Stoner and Pedrosa with a 'completely new' RC213V to try at the test.
Italian MotoGP results: 1. Jorge Lorenzo
2. Dani Pedrosa
3. Andrea Dovizioso
4. Stefan Bradl
5. Valentino Rossi
6. Cal Crutchlow
7. Nicky Hayden
8. Casey Stoner
9. Hector Barbera
10. Alvaro Bautista
11. Ben Spies
12. Randy De Puniet
13. Aleix Espargaro
14. James Ellison
15. Mattia Pasini
16. Ivan Silva
